technologyreview.com: By Emily Singer

Jeff Lichtman hopes to elucidate brain development and disease with new technologies that illuminate the web of neural circuits.

Displayed on Jeff Lichtman’s computer screen in his office at Harvard University is what appears to be an elegant drawing of a tree. Thin multicolored lines snake upward in parallel, then branch out in twos and threes, their tips capped by tiny leaves. Lichtman is a neuroscientist, and the image is the first comprehensive wiring diagram of part of the mammalian nervous system. The lines denote axons, the long, hairlike extensions of nerve cells that transmit signals from one neuron to the next; the leaves are synapses, the connections that the axons make with other neurons or muscle cells. [ read more ]

technologyreview.com: By Emily Singer

Probing the salamander genome reveals clues to its remarkable ability to regrow damaged limbs and organs.

In its own way, the axolotl salamander is a mighty beast. Chop off its leg, and the gilled creature will grow a new one. Freeze part of its heart, and the organ will form anew. Carve out half of its brain, and six months later, another half will have sprouted in its place. “You can do anything to it except kill it, and it will regenerate,” says Gerald Pao, a postdoctoral researcher at the Salk Institute for Biological Studies, in La Jolla, CA.

That extraordinary power of regeneration inspired Pao to probe the axolotl salamander’s DNA. Despite decades of research on the salamander, little is known about its genome. That began to change last year, when Pao and his collaborators won one billion bases’ worth of free sequencing from Roche Applied Science, based in Indianapolis. Now that the data is in, scientists can finally begin the hunt for the genetic program that endows the animal with its unique capabilities. [ read more ]

seedmagazine.com: by Joshua Roebke

A team of physicists in Vienna has devised experiments that may answer one of the enduring riddles of science: Do we create the world just by looking at it?

To enter the somewhat formidable Neo-Renaissance building at Boltzmanngasse 3 in Vienna, you must pass through a small door sawed from the original cathedrallike entrance. When I first visited this past March, it was chilly and overcast in the late afternoon. Atop several tall stories of scaffolding there were two men who would hardly have been visible from the street were it not for their sunrise-orange jumpsuits. As I was about to pass through the nested entrance, I heard a sudden rush of wind and felt a mist of winter drizzle. I glanced up. The veiled workers were power-washing away the building’s façade, down to the century-old brick underneath. [ read more ]

seedmagazine.com: by Peter Ward

If almost every species on Earth was killed some 250 million years ago, how did our ancient ancestors survive and evolve into us?

In the deep history of our planet, there have been at least five short intervals in which the majority of living species suddenly went extinct. Biologists are used to thinking about how environmental pressures slowly select the organisms most fit for survival through natural selection, shaping life on Earth like an artist sculpting clay. However, mass extinctions are drastic examples of natural selection at its most ruthless, killing off vast numbers of species at one time in a way that is hardly typical of evolution. [ read more ]

seedmagazine.com: by Jonah Lehrer

New research is linking dopamine to complex social phenomena and changing neuroscience in the process.

Read Montague is getting frustrated. He’s trying to show me his newest brain scanner, a gleaming white fMRI machine that looks like a gargantuan tanning bed. The door, however, can be unlocked only by a fingerprint scan, which isn’t recognizing Montague’s fingers. Again and again, he inserts his palm under the infrared light, only to get the same beep of rejection. Montague is clearly growing frustrated — “ I can’t get into my own scanning room!” he yells, at no one in particular — but he also appreciates the irony. A pioneer of brain imaging, he oversees one of the premier fMRI setups in the world, and yet he can’t even scan his own hand. “I can image the mind,” he says. “But apparently my thumb is beyond the limits of science.” [ read more ]

dailygalaxy.com: by Casey Kazan.

“Everyone has assumed we age by rust. But how do you explain animals that don’t age? Some tortoises lay eggs at the age of 100, there are whales that live to be 200 and clams that make it past 400 years.”

Stuart Kim, PhD, Stanford University professor of developmental biology and genetics

Prevailing theory of aging challenged by Stanford University Medical School researchers. Their discovery contradicts the prevailing theory that aging is a buildup of tissue damage similar to rust. The Stanford findings suggest specific genetic instructions drive the process. If they are right, science might one day find ways of switching the signals off and halting or even reversing aging. [ read more ]

lifeboat.com:  By Daniel D. Brown.

Ever since the evolution of the sensory neuron, organisms have been using these amazing peepholes into existence to direct the course of their lives. Now, humankind has elevated the role of these senses, and even created technological extensions of them, in order to find order and true knowledge of this Universe in which we exist. We are all scientists looking at the world through our own tiny peepholes, attempting to find our place within it.

We have sought to understand what we are made of, what drives our constant fight against entropy, and what defines us as thinking, living entities. Who knows what the future may hold or what constraints will be placed on our knowledge, whether through considered intellect and experience or through societal and cultural pressures? For the purpose of this article, I am ignoring any social, cultural, or religious implications or constraints that may face the endeavors of science. I simply ask: what questions remain about ourselves and our reality that science may theoretically be able to answer in the future? [ read more ]

technologyreview.com: By Alexandra M. Goho

A fast screening method could help separate the good from the bad.

In light of mounting concerns regarding the potential toxicity of some nanomaterials, scientists have designed a rapid screening tool to help predict which ones are likely to be harmful. Hundreds of nanotechnology-based products are already on the market–in everything from sunscreens and cosmetics to paints and car bumpers–and many more are in the pipeline. However, studies assessing the safety of nanomaterials are limited. As a result, scientists and policy makers have been calling for more systematic reviews of the risks that these nanoscale materials might pose to human health. [ read more ]

physorg.com: With a bit of genetic trickery, researchers at the Stanford University School of Medicine have turned normal skin cells into cancer stem cells, a step that will make these naturally rare cells easier to study.

Cancer stem cells are thought to be the ones that drive a cancer, and are therefore the targets of any cancer therapy that must kill them in order to be effective. Understanding these cells has been a challenge, however, because they are rare, difficult to isolate and don’t grow well in the lab. [ read more ]